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A convenient synthesis of the (E)-monoacetates of 2-alkylidenepropane-1,3-diols.

  作者 Miura, Tsuyoshi;Okazaki, Kenjiro;Ogawa, Kyoko;Otomo, Erika;Umetsu, Satoe;Takahashi, Mauko;Kawashima, Yuya;Jyo, Yuki;Koyata, Naka;Murakami, Yasuoki;Imai, Nobuyuki;  
  选自 期刊  Synthesis;  卷期  2008年-17;  页码  2695-2700  
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[摘要]Various kinds of 3-substituted (E)-2-(hydroxymethyl)prop-2-enyl acetates were conveniently obtained in excellent yields by the regiospecific acetylation of 2-alkylidenepropane-1,3-diols with 10 equiv AcOCH:CH2 in the presence of 50% wt./wt. porcine pancreatic lipase (PPL) type II. The starting materials or (Z)-monoacetate or diacetate byproducts were generally not present.

 
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