Electrocyclization of Oxatrienes in the Construction of Structurally Complex Pyranopyridones

[摘要]：Application of a tandem Knoevenagel/6 pi-electrocyclization sequence is able to produce highly substituted pyranopyridones from moderate to high yields in a one-step reaction. High diasteroselectivity is observed in some cases and was rationalized on the basis of the thermodynamic control of the evidenced reversibility of a 6 pi-electrocyclization reaction. Numerous examples are provided establishing a novel entry in natural product-like structures of pyranopyridone alkaloids.

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