[摘要]：The XY-linker region of somatic cell PLC (phospholipase)-beta, -gamma, -delta and -epsilon isoforms confers potent catalytic inhibition, suggesting a common auto-regulatory role. Surprisingly, the sperm PLC zeta XY-linker does not mediate auto-inhibition. Unlike for somatic PLCs, the absence of the PLC zeta XY-linker significantly diminishes both in vitro PIP(2), (phosphatidylinositol 4,5-bisphosphate) hydrolysis and in vivo Ca(2+) -oscillation-inducing activity, revealing evidence for a novel PLC zeta enzymatic mechanism.
