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GENERATION OF 3-(1H-ISOCHROMEN-1-YL)-1H-INDOLE VIA SILVER TRIFLATE-CATALYZED TANDEM REACTION OF 2-ALKYNYLBENZALDEHYDE WITH INDOLE

  作者 OUYANG BANLAI; YUAN JIANJUN; YANG QIN; DING QIUPING; PENG YIYUAN; WU JIE  
  选自 期刊  Heterocycles;  卷期  2011年82-2;  页码  1239-+  
  关联知识点  
 

[摘要]A facile and efficient method is developed for synthesis of 3-(1H-isochromen-1-yl)-1H-indole via silver triflate-catalyzed tandem reaction of 2-alkynylbenzaldehyde with indole. The reaction proceeds smoothly in DMF at room temperature with good substrate generality. The availability of the starting materials combined with mild reaction conditions and the high efficiency of this synthetic route would be attractive and beneficial for the focused library construction.

 
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