Triazine Compounds as Antagonists at Bv8-Prokineticin Receptors.

[摘要]：We approached a new synthesis of some 1,3,5-triazine-4,6-diones as potential non peptidic prokineticin receptor antagonists, contg. the following substitutions: N1 and N5 are linked to 4-methoxybenzyl and 4-ethylbenzyl groups; C2 is linked to an amino-ethyl-guanidine or an amino-ethyl-amino-2-imidazoline group. New compds. were assessed for PKR1 and PKR2 affinity. Antagonist properties were evaluated as inhibition of 1 nM Bv8-induced intracellular Ca2+ mobilization.

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