[摘要]：In this study, we found that expression and secretion of galectin-3 (GAL-3) were upregulated by amyloid-beta 42 (A beta 42) exposure in human umbilical cord blood-derived mesenchymal stem cell (hUCB-MSC) without cell death. A beta 42-exposed rat primary cortical neuronal cells co-treated with recombinant GAL-3 were protected from neuronal death in a dose-dependent manner. hUCB-MSCs were cocultured with A beta 42-exposed rat primary neuronal cells or the neuroblastoma cell line, SH-SY5Y in a Transwell chamber. Coculture of hUCB-MSCs reduced cell death of A beta 42-exposed neurons and SH-SY5Y cells. This neuroprotective effect of hUCB-MSCs was reduced significantly by GAL-3 siRNA. These data suggested that hUCB-MSC-derived GAL-3 is a survival factor against A beta 42 neurotoxicity. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
