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Targeting cancer cells with controlled release nanocapsules based on a single aptamer

  作者 HERNANDEZ FRANK J; HERNANDEZ LUIZA I; PINTO ALESSANDRO; SCHAEFER THOMAS; OZALP VELI C  
  选自 期刊  Chemical Communications;  卷期  2013年49-13;  页码  1285-1287  
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[摘要]Molecular gates have received considerable attention as drug delivery systems. More recently, aptamer-based gates showed great potential in overcoming major challenges associated with drug delivery by means of nanocapsules. Based on a switchable aptamer nanovalves approach, we herein report the first demonstration of an engineered single molecular gate that directs nanoparticles to cancer cells and subsequently delivers the payload in a controllable fashion.

 
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