Acylated Triterpene Saponins from Atroxima liberica STAPF

[摘要]：The four new acylated triterpene saponins 14, isolated as two pairs of isomers and named libericosides A1/A2 and B1/B2, one pair of isomers 5/6, the (Z)-isomer libericoside C2 (5) being new, one new sucrose ester, atroximoside (7), and eight known compounds were isolated from the roots of Atroxima liberica by repeated MPLC and VLC on normal and reversed-phase silica gel. Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies (1H- and 13C-NMR, DEPT, COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3-O-beta-D-glucopyranosylpresenegenin 28-{O-a-L-arabinopyranosyl-(1 > 3)-O-beta-D-xylopyranosyl-(1 > 4)-O-a-L-rhamnopyranosyl-(1 > 2)-4-O-[(E)-3,4-dimethoxycinnamoyl]-beta-D-fucopyranosyl} ester (1) and its (Z)-isomer 2, 3-O-alpha-D-glucopyranosylpresenegenin 28-{O-a-L-arabinopyranosyl-(1 > 4)-O-beta-D-xylopyranosyl-(1 > 4)-O-a-L-rhamnopyranosyl-(1 > 2)-O-[O-beta-D-xylopyranosyl-(1 > 3)-beta-D-glucopyranosyl-(1 > 3)]-4-O-[(E)-3,4-dimethoxycinnamoyl]-beta-D-fucopyranosyl} ester (3) and its (Z)-isomer 4, 3-O-beta-D-glucopyranosylpresenegenin 28-{O-beta-D-xylopyranosyl-(1 > 4)-O-a-L-rhamnopyranosyl-(1?2)-O-[6-O-acetyl-beta-D-glucopyranosyl-(1 > 3)]-4-O-[(Z)-3,4-dimethoxycinnamoyl]-beta-D-fucopyranosyl} ester (5), and 3-O-[(Z)-feruloyl]-beta-D-fructofuranosyl a-D-glucopyranoside (7). Compounds 16 and the known saponins 8/9 were evaluated against the human colon cancer cells HCT 116 and HT-29 and showed moderate to weak cytotoxicity.

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