Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)-Carissone.

[摘要]：palladium-catalyzed enantioselective alkylation of vinylogous ester substrates forged the C(10) all-carbon quaternary center. This key transformation enabled a diastereoselective olefin hydrogenation to create the syn stereochem. at C(7). The devised synthetic strategy allowed for the prepn. of the antibacterial agent (+)-carissone (I) and a formal synthesis of the P/Q-type calcium channel blocker (-)-a-eudesmol.

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