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[摘要]:Novel optically active axially chiral amino acid and amino acid and amino alcohols have been synthesized efficiently via lactam ring-opening, with the aid of an optically active alcohol amidoaza[5]helicene 5, which has been readily prepared by an additive-ligand-free Pd catalyzed domino coupling reaction in a single step. The stereostructures of these chiral molecules have also been clarified. |
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