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[摘要]:In this paper. we report a facile synthesis of 2-carbamoyl-2-cyanocyclopropanecarboxylates through a tandem iodosobenzene/tetrabutylammonium iodide-induced oxidative cyclization and a subsequent neighboring group-assisted decarboxylation of the Michael adducts of 2-eyanoacetamides with alpha,beta-unsaturated malonates. This method affords the desired highly functionalized cyclopropanes in moderate to good yields and with excellent chastereo selectivities. In addition, the reaction proceeds smoothly under mild conditions and with good functional group tolerance |
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