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Ferrier-Petasis Rearrangement of 4-(Vinyloxy)azetidin-2-ones: An Entry to Carbapenams and Carbacephams

  作者 KOZIOL ANNA; GIZESCZYK BARBARA; KOZIOL ANDIZEJ; STASZEWSKAKRAJEWSKA OLGA; FUIMAN BARILONNEJ; CHMIELEWSKI MAREK  
  选自 期刊  Journal of Organic Chemistry;  卷期  2010年75-20;  页码  6990-6993  
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[摘要]Trimethylsilyl inflate promotes Ferrier-Petasis rear range-ment of 4-(vinyloxy)-4-(propenyloxy)-. and 4-(isopiopenyloxy)azetichn-2-ones to corresponding 4-(carbonyimethyl)azetidin-2-ones The latter compounds may serve as attractive intermediates in the synthesis of carbapenem antibiotics To illustrate the potential of this reaction. selected real rangement pi ducts have been transformed into carbapenams

 
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