Tetrakis(trimethylsilyl) Ethenylidene-1,1-bisphosphonate: A Mild and Convenient Michael Acceptor for the Synthesis of 2-Aminoethylidene-1,1-bisphosphonic Acids and Their Potassium Salts

[摘要]：A straightforward synthesis of highly functionalized 2-aminoethylidene-1,1-bisphosphonic acids via the Michael addition of amines to easily available tetrakis(trimethylsilyl) ethenylidene-1,1-bisphosphonate, H2C= C[P(O)(OTMS)(2)](2), has been described. The potassium salts of the title compounds were also easily achieved in high yield by reacting the Michael adducts with potassium fluoride.

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