Bioorganic & Medicinal Chemistry Letters ——个性化文献订阅—

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Triterpene based compounds with potent anti-maturation activity against HIV-1

作者	Gerrish, D; Kim, IC; Kumar, DV; Austin, H; Garrus, JE; Baichwal, V; Saunders, M; McKinnon, RS; Anderson, MB; Carlson, R; Arranz-Plaza, E; Yager, KM

选自	期刊 Bioorganic & Medicinal Chemistry Letters; 卷期 2008年18-24; 页码 6971-6380

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[摘要]：Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats. (C) 2008 Elsevier Ltd. All rights reserved.
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