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[摘要]:The intramolecular acid catalyzed aldol cyclization of 2,3,7-triketoesters formed from zeta-keto-alpha-diazo-beta-ketoesters provides highly functionalized cyclopentanones with good diastereoselectivity in high overall yields via kinetically controlled and stereodivergent catalytic processes. Lewis acid catalysis gives high selectivity for the 1,2-anti tetrasubstituted cyclopentanones, whereas Bronsted acid catalysis produces the corresponding 1,2-syn diastereomer. |
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