AN EFFICIENT SYNTHESIS OF 3-SUBSTITUTED 3H-ISOBENZOFURAN-1-YLIDENAMINES BY THE REACTION OF 2-CYANOBENZALDEHYDES WITH ORGANOLITHIUMS AND THEIR CONVERSION INTO ISOBENZOFURAN-1(3H)-ONES

[摘要]：A new and efficient synthesis of 3-substituted 3H-isobenzofuran-1-ylidenamines by the reaction of 2-cyanobenzaldehydes with nucleophiles, such as organolithiums or lithium enolates of t-butyl acetate and N,N-dimethylacetamide, is reported. Some of these products were converted into the corresponding 3-substituted isobenzofuran-1(3H)-ones (phthalides) upon treatment with hydrochloric acid in satisfactory yields.

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