【文章名】A short enantioselective formal synthesis of (+)-(S)-4,4-(ethylenedioxy)-7-hydroxyoct-2-enoic acid: The penultimate precursor to (-)-(R,R)-pyranophorin
A short enantioselective formal synthesis of (+)-(S)-4,4-(ethylenedioxy)-7-hydroxyoct-2-enoic acid: The penultimate precursor to (-)-(R,R)-pyranophorin
作者
Kalita, D; Khan, AT; Saikia, AK; Bez, G; Barua, NC
[摘要]：Exclusive trans-addition of the nitronate dianion generated from the readily available (S)-4-acetoxy-1-nitropentane (S)-3 to methyl propiolate under PTC conditions gave adduct 4, which under carefully controlled Nef conditions at pH 5.3 gave the crucial gamma-oxo-alpha,beta-unsaturated ester (S)-5.
