[摘要]：The role of specific members of the NF-kappa B family of transcription factors in CD8 T-cell selection and development is largely unknown. Here, we show that mice lacking NF-kappa B1 develop a unique population of conventional CD8 single-positive (SP) thymocytes with memory T cell-like properties that populate peripheral immune organs. Development of this memory-like population is not due to PLZF(+) thymocytes and instead coincides with changes in CD8 T-cell selection. These include a reduction in the efficiency of negative selection and a dependence on MHC class Ia or Ib expressed by haematopoietic cells. These findings indicate that NF-kappa B1 regulates multiple events in the thymus that collectively inhibit the excess development of CD8(+) thymocytes with memory cell characteristics. The EMBO Journal (2012) 31, 692-706. doi: 10.1038/emboj.2011.435; Published online 29 November 2011
