[摘要]:An efficient DABCO-mediated regio- and diastereoselective substitution of Baylis-Hillman acetates with p-toluenesulfonylmethyl isocyanide (TosMIC) has been developed via a tandem S(N)2'-S(N)2' mechanism. The products were obtained in excellent yields (80-92%) and in moderate diastereoselectivity (66-80%). |