New Thiochromans via Reductive Cyclization of Thiophenol Derivatives

[摘要]：Reductive cyclization of sulfur-containing substrates 1 and 5 with samarium diiodide afforded the corresponding thiochroman derivatives with excellent diastereoselectivities. Cyclization of 1 is facilitated by geminal dimethyl substitution, which accelerates the reductive coupling and prevents samarium diiodide induced dehalogenation. Bromo-substituted dihydrothiochroman derivative 8 was further functionalized in subsequent reactions. Analogously, bromo-substituted hexahydroquinoline derivative 10 was diastereoselectively prepared in satisfying yield.

[全文传递流程]：

一般上传文献全文的时限在1个工作日内