[摘要]：A chiral amine-triggered highly enantio-and diastereoselective synthesis yielding 69-94% of cis-decahydroquinolines is reported. The synthetic protocol involves a [2+2+2]-annulation via (S)-diphenylprolinol trimethylsilyl ether catalyzed Michael addition of cyclohexanone to nitroalkenes followed by aza-Henryhemiaminalization reaction cascade. The process stereoselectively installs five contiguous chiral centers into the quinoline structure. |
