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[摘要]:A concise synthesis of fused bicyclic pyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides is reported. The exo cycloadduct isomer enables the synthesis of a novel cyclic amidine toward the preparation of a potential human histamine H4 receptor antagonist. The minor endo isomer led to the isolation of a new triazine ring through an intramolecular reductive cyclisation. |
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