The stability/reactivity effects of trifluoromethyl and perfluoroalkyl chains in a masked 1,3-dicarbonyl derivative: the case of 1-acetoxy-1-iodo-2-(perfluoroalkyl)ethanes.

[摘要]：A review. The development of an efficient and general trifluoromethylation or perfluoroalkylation method is a major challenge in org. chem. This account presents the breakthrough realized in this field using polyfluoroalkylated gem-iodoacetoxy derivs. which are useful synthons for the short prepn. of various fluorinated org. compds. The main body of this account highlights several applications of these new derivs. as starting blocks for diverse regiospecific syntheses of trifluoromethyl- and perfluoroalkyl-contg. heterocyclic compds. A brief discussion of the use of a new method for the detn. of the configuration and conformation of push-pull perfluoroalkyl-contg. olefinic derivs. using coupling const. 4JCF is included.

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