Synthesis and Antimicrobial Activity of Some 7-Aryl-5,6-dihydro-14aza[1]benzopyrano[3,4-b]phenanthren-8H-ones

[摘要]：The title compounds, 7-aryl-5,6-dihydro-14-aza[1]benzopyrano[3,4-b]phenanthren-8H-ones 3a-l have been synthesized by reacting various 4-hydroxy coumarins 1a-c with 2-arylidene-1-tetralones 2a-d in the presence of ammonium acetate and acetic acid under Krohnke's reaction condition. The structures of all the synthesized compounds were supported by analytical, IR, (1)H-NMR, and (13)C-NMR data. All the synthesized compounds 3a-l have been screened for their antibacterial activities against Escherichia coli (Gram -ve bacteria), Bacillus subtilis (Gram +ve bacteria), and antifungal activity against Candida albicans (Fungi).

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