Synthesis of Spiro Thiazolo[3,2-a]pyrimidine Compounds by One-Pot Sequential 1,3-Dipolar Cycloadditions

[摘要]：A new class of spiro thiazolo[3,2-a]pyrimidine compounds were synthesized by the one-pot sequential 1,3-dipolar cycloaddition of azomethine ylide (generated from isatin and sarcosine) nitrile oxide to 2-arylmethylidene-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidin-3-ones in moderate yields. The structures of all the products were characterized thoroughly by NMR, MS, IR, elemental analysis, and NMR together with X-ray crystallographic analysis.

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