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A Practical Synthesis of (-)-Kainic Acid

  作者 TAKITA SATOSHI; YOKOSHIMA SATOSHI; FUKUYAMA TOHRU  
  选自 期刊  Synthesis;  卷期  2011年-23;  页码  3848-3858  
  关联知识点  
 

[摘要]A highly practical total synthesis of (-)-kainic acid has been accomplished. The synthesis features the stereoselective alkylation of an iodolactone intermediate efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerization.

 
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