Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation
作者
OSLOB JOHAN D; JOHNSON RUSSELL J; CAI HAIYING; FENG SHIRLEY Q; HU LILY; KOSAKA YUKO; LAI JULIE; SIVARAJA MOHANRAM; TEP SAMNANG; YANG HANBIAO; ZAHARIA CRISTIANA A; EVANCHIK MARC J; MCDOWELL ROBERT S
[摘要]：Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue (compound 19) also inhibits rat FASN and inhibits de novo palmitate synthesis in vitro (cell-based) as well as in vivo.
