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Straightforward Conversion of Arene Carboxylic Acids into Aryl Nitriles by Palladium-Catalyzed Decarboxylative Cyanation Reaction

  作者 OUCHAOU KAHINA; GEORGIN DOMINIQUE; TARAN FREDERIC  
  选自 期刊  SYNLETT;  卷期  2010年-14;  页码  2083-2086  
  关联知识点  
 

[摘要]A one-pot procedure to convert aromatic carboxylic acids into aromatic nitriles is described. The methodology is based on a palladium(II)-catalyzed decarboxylative cyanation reaction using cyanohydrins as soluble cyanide sources. The described reaction worked on a panel of substrates and is additionally of particular interest for the straightforward preparation of C-13- or C-14-labeled compounds.

 
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