Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with beta-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

[摘要]：The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and beta-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.

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