[摘要]:A new indole alkaloid, streptomycindole (1), and a known related compound, N-phenylacetyl-L-tryptophan (2), have been isolated from Streptomyces sp. DA22, associated with South China Sea sponge Craniella australiensis. Their structures were established on the basis of a combination of mass spectrometry, 1H- and (13)C-NMR spectroscopic analyses, and chemical methods.