An efficient one-pot synthesis of pyrimido[2,1-b][1,3]oxazine derivatives via the reaction of isocyanides with dialkyl acetylenedicarboxylates in the presence of 5-substituted uracils

[摘要]：The reactive 1:1 intermediate produced in the reaction between alkyl isocyanides and dialkyl acetylenedicarboxylates was trapped by uracil and its 5-substituted derivatives to yield highly functionalized pyrimido[2,1-b][1,3]oxazine derivatives in fairly good yields. J. Heterocyclic Chem.,(2011).

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