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[摘要]:A practical and high-yielding method for the synthesis of new sultams from readily available sulfonamides, 1-naphthylamine, and 2-halobenzyl bromides is reported. A variety of tricyclic, tetracyclic, and pentacyclic sultams have been prepared via palladium-catalyzed, ligand-free intramolecular cyclization. Detailed mechanistic studies of the reaction pathway are also described. |
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