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[摘要]:A straightforward method for the synthesis of 2-amino-3,4-dihydroquinazolines from Baylis-Hillman derivatives is disclosed. The protocol involves sequential S(N)2 reaction of a primary airline on the Baylis-Hillman acetate derived from 2-nitrobenzaldehyde, cyanogen bromide-mediated nitrile addition, and iron-acetic acid promoted reductive cyclization. This approach is also applied to the preparation of imidazol[2,1-b]quinazoline-2-ones and imidazo[2,1-b]quinazolines in one pot. |
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