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Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

  作者 Yun, JY; Rago, C; Cheong, I; Pagliarini, R; Angenendt, P; Rajagopalan, H; Schmidt, K; Willson, JKV; Markowitz, S; Zhou, SB; Diaz, LA; Velculescu, VE; Lengauer, C; Kinzler, KW; Vogelstein, B; Papadopoulos, N  
  选自 期刊  Science;  卷期  2009年325-5947;  页码  1555-1559  
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[摘要]Tumor progression is driven by genetic mutations, but little is known about the environmental conditions that select for these mutations. Studying the transcriptomes of paired colorectal cancer cell lines that differed only in the mutational status of the

 
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