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Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)

  作者 Kuduk, SD; Chang, RK; Wai, JMC; Di Marco, CN; Cofre, V; DiPardo, RM; Cook, SP; Cato, MJ; Jovanovska, A; Urban, MO; Leitl, M; Spencer, RH; Kane, SA; Hartman, GD; Bilodeau, MT  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2009年19-15;  页码  4059-4063  
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[摘要]A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain. (C) 2009 Elsevier Ltd. All rights reserved.

 
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