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Bioactive cembrane diterpenoids of Anisomeles indica

  作者 Chen, YL; Lan, YH; Hsieh, PW; Wu, CC; Chen, SL; Yen, CT; Changt, FR; Hung, WC; Wu, YC  
  选自 期刊  Journal of natural products;  卷期  2008年71-7;  页码  1207-1212  
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[摘要]Five new cembrane-type diterpenoids with a trans-fused (alpha-methylene-gamma-lactone (1-5), a new flavonoid glucoside (6), and 17 known compounds were,isolated from a methanol extract of Anisomeles indica. The structures of 1-6 were elucidated by spectroscopic analysis, and the absolute configuration of compound 1 was determined using the modified Mosher's method. Compound 8 (4,5-epoxovatodiolide) exhibited cytotoxicity against a small panel of human cancer cell lines. Additionally, compounds 4 and 7 (ovatodiolide) exhibited selective antiplatelet aggregation activities toward collagen, while compounds 4, 5, and 8 showed inhibitory effects on antiplatelet aggregation induced by thrombin.

 
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