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Facile One-Pot Synthesis of Carbamoylbenzotriazoles Directly from CO(2): Synthesis of Tolbutamide

  作者 HUNTER ROGER; MSUTU ATHENKOSI; DWYER CATHY L; EMSLIE NEVILLE D; HUNT RAYMOND C; BEZUIDENHOUDT BAREND C B  
  选自 期刊  SYNLETT;  卷期  2011年-16;  页码  2335-2338  
  关联知识点  
 

[摘要]CO(2) gas trapped with a primary or secondary amine as a carbamate salt in the presence of DBU reacts with triphenylphosphine and 1-chlorobenzotriazole (BtCl) to form a carbamoylbenzotriazole urea, which reacts with para-toluenesulfonamide under solvent-free conditions to produce N-sulfonyl ureas such as tolbutamide.

 
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