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Highly Enantioselective Three-Component Reactions of tert-Butyl Diazoacetate with Arylamines and Imines: An Efficient Synthesis of alpha,beta-Bis(arylamino) Acid Derivatives

  作者 JIANG LIQIN; ZHANG DAN; WANG ZHONGQING; HU WENHAO  
  选自 期刊  Synthesis;  卷期  2013年45-4;  页码  452-458  
  关联知识点  
 

[摘要]Enantioselective three-component reactions of tert-butyl diazoacetate with arylamines and imines afford alpha,beta-bis(arylamino) acid derivatives in good yields (56-90%) with high diastereoselectivities (up to >95:5 dr) and excellent enantioselectivities (up to 96% ee).

 
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