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Efficient synthesis of 2-mono- and 2,3-disubstituted indoles via palladium-catalyzed oxidation of amino alcohols.

  作者 Aoyagi, Yutaka;Shishikura, Masahiro;Mizusaki, Toshihiko;Komine, Takashi;Yoshinaga, Tokuji;Inaba, Haruko;Ohta, Akihiro;Takeya, Koichi;  
  选自 期刊  Heterocycles;  卷期  2008年75-5;  页码  1055-1059  
  关联知识点  
 

[摘要]Amino alcs., obtained by reaction of N-protected o-toluidines or 2-ethylanilines with aldehydes, were deprotected and cyclized in the presence of Pd(PPh3)4 to give indoles (I; R = H, Me; R1 = alkyl, cyclohexyl, phenethyl).

 
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