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Synthesis and structure-activity relationship (SAR) study of 4-azabenzoxazole analogues as H-3 antagonists

  作者 Shao, N; Aslanian, R; West, RE; Williams, SM; Wu, RL; Hwa, J; Sondey, C; Lachowicz, J; Palani, A  
  选自 期刊  Bioorganic & Medicinal Chemistry Letters;  卷期  2012年22-5;  页码  2075-2078  
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[摘要]The synthesis and SAR of a novel series of 4-azabenzoxazole histamine H-3 antagonists is described. Introduction of substituted phenyl, pyridyl and fused heterocyclic groups to the 6-position of the 4-azabenzoxazole core gave a series of compounds with good H-3 antagonist activity in both ex vivo and in vivo assays. (C) 2012 Elsevier Ltd. All rights reserved.

 
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