Copper-Catalyzed Synthesis of 2, 4-Disubstituted Allenoates from alpha-Diazoesters

[摘要]：A Cu-catalyzed method for coupling alpha-substituted-alpha-diazoesters with terminal alkynes to give substituted allenoates is described. Key to the development of a selective method was the recognition that an adventitous base catalyzes the isomerization to form the allenoate product. A plausible mechanism is proposed, based in part on evidence against a mechanism that involves a Cu(I)-acetylide as a low-valent intermediate.

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