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Antineoplastic Agents. 454. Synthesis of the Strong Cancer Cell Growth Inhibitors trans-Dihydronarciclasine and 7-Deoxy-trans-dihydronarciclasine

  作者 Pettit, GR; Ducki, S; Eastham, SA; Melody, N  
  选自 期刊  Journal of natural products;  卷期  2009年72-7;  页码  1279-1282  
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[摘要]To further pursue the antineoplastic leads offered by Our isolation of trans-dihydronarciclasine (1a) and 7-deoxy-trans-dihydronarciclasine (1c) from two medicinal plant species of the Amaryllidaceae family, a practical palladium-catalyzed hydrogenation procedure was developed for the synthesis of these isocarbostyrils from narciclasine (2a) and 7-deoxynarciclasine (2c).

 
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