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Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27(KIP1) expression and suppressing NOTCH signaling

  作者 Hammerle, B; Ulin, E; Guimera, J; Becker, W; Guillemot, F; Tejedor, FJ  
  选自 期刊  Development;  卷期  2011年138-12;  页码  2543-2554  
  关联知识点  
 

[摘要]The decision of a neural precursor to stop dividing and begin its terminal differentiation at the correct place, and at the right time, is a crucial step in the generation of cell diversity in the nervous system. Here, we show that the Down's syndrome can

 
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