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Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation

  作者 Marks, SA; Kalderon, D  
  选自 期刊  Development;  卷期  2011年138-12;  页码  2533-2542  
  关联知识点  
 

[摘要]Hedgehog (Hh) signaling activates full-length Ci/Gli family transcription factors and prevents Ci/Gli proteolytic processing to repressor forms. In the absence of Hh, Ci/Gli processing is initiated by direct Pka phosphorylation. Despite those fundamental

 
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