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Carbon Dioxide as the C1 Source for Direct C-H Functionalization of Aromatic Heterocycles

  作者 VECHORKIN OLEG; HIRT NATHALIE; HU XILE  
  选自 期刊  Organic Letters;  卷期  2010年12-15;  页码  3567-3569  
  关联知识点  
 

[摘要]A simple and straightforward method has been developed for the direct carboxylation of aromatic heterocylces such as oxazoles, thiazoles, and oxadiazoles using CO2 as the C1 source. The reactions require no metal catalyst and only Cs2CO3 as the base. A good functional group tolerance is achieved.

 
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