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[摘要]：A general method for synthesizing a-hydroxy N-acylindoles In one-pot via an acid-catalyzed condensation of a convertible isonitrile with water and various aldehydes Is presented. These intermediates were incorporated into poly(alpha-hydroxy acid) copolymers bearing residues with functionalizable side chains, which could be further modified through Cu(I)-catalyzed azide-alkyne cylcoaddition reactions. This versatile synthetic strategy provides access to side chain functionalized poly(alpha-hydroxy acid) copolymers from readily available aldehydes, making it potentially useful as an approach to synthesize biodegradable polymers with new, tunable properties. |
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