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[摘要]:Estrogen receptor ER alpha and ER beta heterodimerization has been implicated in cancer chemoprevention. The discovery, structural elucidation, and total synthesis of a new natural product, actinopolymorphol A (1), from Actinopolymorpha rutilus (YIM45725) that preferentially induces ER alpha/beta heterodimerization is reported. Total synthesis of 1 has allowed us to determine Its absolute stereochemistry and that of a previously known deacetylated congener, and 1 represents the first member of a new class of natural products not previously recognized to modulate ER function. |
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