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[摘要]:A convergent synthesis of the macrolide core as the immediate precursor to amphidinolide H1 is described, which features a palladium-catalyzed Stille cross-coupling, a Me ketone diastereoselective aldol reaction, a Mitsunobu esterification, and an intramol. ring-closing metathesis (RCM) reaction to construct the 26-membered macrocycle as key steps. |
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