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Synthetic studies toward the total synthesis of amphidinolide H1.

  作者 Deng, Lisheng;Ma, Zhixiong;Zhao, Gang;  
  选自 期刊  SYNLETT;  卷期  2008年-5;  页码  728-732  
  关联知识点  
 

[摘要]A convergent synthesis of the macrolide core as the immediate precursor to amphidinolide H1 is described, which features a palladium-catalyzed Stille cross-coupling, a Me ketone diastereoselective aldol reaction, a Mitsunobu esterification, and an intramol. ring-closing metathesis (RCM) reaction to construct the 26-membered macrocycle as key steps.

 
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