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Formal [4+1] Annulation of Cyclopropyl Amides and Water Mediated by Lewis Acid: A Novel Entry to gamma-Butyrolactones

  作者 ZHANG DINGYUAN; ZHANG RUI; LIANG YONGJIU; DONG DEWEN  
  选自 期刊  Synthesis;  卷期  2012年44-11;  页码  1679-1685  
  关联知识点  
 

[摘要]An efficient one-pot synthesis of substituted gamma-butyrolactones from cyclopropyl amides mediated by the Lewis acid SnCl4 center dot 5H(2)O is reported. A mechanism involving a tandem ring-opening reaction and intramolecular cyclization reaction is proposed.

 
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