Three-Component, One-Flask Synthesis of Rhodanines (Thiazolidinones)

[摘要]：5-(Z)-Alkylidene-2-thioxo-1,3-thiazolidin-4-ones (rhodanine derivatives) were prepared by reaction of in situ generated dithiocarbarnates with recently reported racemic alpha-chloro-beta,gamma-alkenoate esters. This multi-component sequential transformation performed in one reaction flask represents a general route to this medicinally valuable class of sulfur/nitrogen heterocycles. Using this convergent procedure, we prepared an analogue of the drug epalrestat, an aldose reductase inhibitory rhodanine.

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